✦ LIBER ✦
Electrophile-induced cyclization of γ,δ-alkenylimines as a synthetic route to pyrrolidines and piperidines
✍ Scribed by Norbert de Kimpe; Mark Boelens; Johan Piqueur; Jan Baele
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 272 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Cyciiition of r,b-alkenylimines with bromine in dichloromethane gave instantaneous formation of cyclic iminium bromides, which were converted into either pyrrolidines or piperidines, depending upon the substitution pattern. This reaction has been applied in the synthesis of 2.azaspiro compounds.