A Simple Approach to 2',3'-Didehydro-2',3'-dideoxynucleosides. -Radical deoxygenation of bis-O-thioxocarbamates prepared from vicinal diols and phenyl isothiocyanate results
✦ LIBER ✦
Radical-based transformation of vicinal diols to olefins via thioxocarbamate derivatives: a simple approach to 2′,3′-didehydro-2′,3′-dideoxynucleosides
✍ Scribed by Makoto Oba; Mitsuteru Suyama; Atsushi Shimamura; Kozaburo Nishiyama
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 161 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The reaction of enamine (I) with ethyl hemiacetal (II) followed by acid hydrolysis and subsequent reduction of the intermediate aldehyde gives rise to the diastereomeric mixture of diols (III) and (IV).