✦ LIBER ✦

Radiation leukemogenesis: Quantitative relationship between pre-leukemic cells in the thymus and lymphoma induction

✍ Scribed by M. Kotler; R. Ruchlemer; O. Avni; E. Yefenof

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 938 KB
Volume: 56
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910560525

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✦ Synopsis

Fractionated irradiation of C57BL/6 mice induces a population of pre-leukemic (PL) cells that progress into mature thymic lymphomas after a latency of 4 to 6 months. Transfer of graded numbers of thymocytes from an irradiated mouse into recipient mice indicated that PL cells first appear in the thymus 6 weeks after irradiation. The initial proportion of the thymic PL cells is 2 I O-' and their frequency continuously increases with time, reaching 5

10 weeks after irradiation. The PL cell population that emerges early during the pre-malignant latency consists of pleioclonal T lymphocytes. However, within 4 weeks a dominant PL clone can be detected which becomes the progenitor of a clonal lymphoma 9 to I 5 weeks later. These results suggest that radiation leukemogenesis involves continuous accumulation of pleioclonal PL cells in the thymus, one of which is then selected for further maturation into frank lymphoma.

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