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Studies on the relationship between thymus regeneration and lymphoma prevention in c57bl/6 mice irradiated and injected with syngeneic spleen cells

✍ Scribed by Louise Chen


Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
531 KB
Volume
7
Category
Article
ISSN
0020-7136

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✦ Synopsis


Abstract

Adult syngeneic spleen cells, which protect against radiogenic lymphoma, failed to induce thymus recovery after irradiation. However, bone‐marrow cells, which afford the same protection against lymphoma induction, are effective in promoting thymus regeneration. Similar observations were made in the experiments on incorporation of ^3^H‐thymidine and ^14^C‐phenyl alanine into thymuses of mice irradiated and injected with spleen or bone‐marrow cells.

It appears that there are two different factors by which haematopoietic cells independently promote thymus regeneration and prevent lymphoma induction.