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Radiation enhancement of radiolabelled antibody deposition in tumors

✍ Scribed by James S. Msirikale; Jerry L. Klein; John Schroeder; Stanley E. Order


Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
758 KB
Volume
13
Category
Article
ISSN
0360-3016

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A syngeneic anti-idiotype monoclonal antibody (MAb) (CM-I I) directed against an anti-carcinoembryonic antigen (CEA) murine MAb (NP-4) was evaluated as a second antibody (SA) to promote the rapid clearance of radiolabeled NP-4 from the blood. Initial studies confirmed that CM-I I IgG removed l3Il-NP