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Racemization-free and efficient peptide synthesis by the carbodiimide method using 1-hydroxybenzotriazole and copper(II) chloride simultaneously as additives

✍ Scribed by Miyazawa, Toshifumi; Otomatsu, Toshihiko; Fukui, Yoshimasa; Yamada, Takashi; Kuwata, Shigeru

Book ID: 120037157
Publisher: The Royal Society of Chemistry
Year: 1988
Tongue: English
Weight: 213 KB
Volume: 6
Category: Article
ISSN: 0022-4936
DOI: 10.1039/C39880000419

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Simultaneous use of 1-hydroxybenzotriazo

Simultaneous use of 1-hydroxybenzotriazole and copper(II) chloride as additives for racemization-free and efficient peptide synthesis by the carbodiimide method

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Copper(II) chloride as a new, efficient

Copper(II) chloride as a new, efficient additive suppressing racemization in peptide synthesis by the carbodiimide method

✍ Toshifumi Miyazawa; Toshihiko Otomatsu; Takashi Yamada; Shigeru Kuwata 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 142 KB

Copper chloride was found to be an extremely efficient additive suppressing racemization in the carbodiimide mediated couplings. The use of additives in the dicyclohexylcarbodiimide (DCC) method is an important improvement contributing to the suppression of racemization in segment couplings. Among a