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Simultaneous use of 1-hydroxybenzotriazole and copper(II) chloride as additives for racemization-free and efficient peptide synthesis by the carbodiimide method

✍ Scribed by MIYAZAWA, TOSHIFUMI ;OTOMATSU, TOSHIHIKO ;FUKUI, YOSHIMASA ;YAMADA, TAKASHI ;KUWATA, SHIGERU

Book ID: 115099414
Publisher: Wiley (Blackwell Publishing)
Year: 2009
Tongue: English
Weight: 596 KB
Volume: 39
Category: Article
ISSN: 0367-8377
DOI: 10.1111/j.1399-3011.1992.tb01590.x

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Copper(II) chloride as a new, efficient

Copper(II) chloride as a new, efficient additive suppressing racemization in peptide synthesis by the carbodiimide method

✍ Toshifumi Miyazawa; Toshihiko Otomatsu; Takashi Yamada; Shigeru Kuwata 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 142 KB

Copper chloride was found to be an extremely efficient additive suppressing racemization in the carbodiimide mediated couplings. The use of additives in the dicyclohexylcarbodiimide (DCC) method is an important improvement contributing to the suppression of racemization in segment couplings. Among a