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Racemization during use of polymeric supports in peptide syntheses

โœ Scribed by D.R. Lauren; R.E. Williams

Publisher
Elsevier Science
Year
1972
Tongue
French
Weight
192 KB
Volume
13
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Recently, a great deal of interest has been shown in the use of polymeric reagents for the automation of peptide synthesis using a solid-phase reaction system. The resin reported by Merrlfield has already been widely used (1,2), and several newer resins seem to have even more potential, since they would allow purification of the intermediate products during an extended synthesis (3-7). Most of these newer polymers fall into two categories: those

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Suppression of racemization during pepti
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โœ Thomas H. Applewhite; Jane S. Nelson ๐Ÿ“‚ Article ๐Ÿ“… 1964 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 301 KB

Current interest (1.2,3) in the base-catalyzed racemiaation of activated derivatives of N-protected amino acids and the continuing importance of this problem prompts us to report results of studies on the suppression of racemieation during the use of the mixed cerboxylic-carbonic anhydride method (4

Use of Marfey's reagent to quantitate ra
Use of Marfey's reagent to quantitate racemization upon anchoring of amino acids to solid supports for peptide synthesis
โœ J. Gordon Adamson; Thang Hoang; Anna Crivici; Gilles A. Lajoie ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 517 KB

A chromatographic assay has been developed to quantitate racemization occurring during attachment of protected amino acids to peptide synthesis resins. Acidolytic cleavage of deprotected amino acids from supports and subsequent derivatization with 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide (Marfey