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R-Spondin mediated canonical Wnt signaling regulates angiogenesis in zebrafish

✍ Scribed by Aniket V. Gore; Brant M. Weinstein


Book ID
116977720
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
53 KB
Volume
331
Category
Article
ISSN
0012-1606

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R-spondins are newly recognized players
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Objective. Clinical and in vitro studies suggest that altered osteogenesis or bone remodeling is involved in the progression and/or onset of osteoarthritis (OA). Wnt signaling plays a key role in osteogenesis via the canonical Wnt/␀-catenin signaling pathway. Two of the R-spondins, Rspo-1 and Rspo-2