Objective. Clinical and in vitro studies suggest that altered osteogenesis or bone remodeling is involved in the progression and/or onset of osteoarthritis (OA). Wnt signaling plays a key role in osteogenesis via the canonical Wnt/-catenin signaling pathway. Two of the R-spondins, Rspo-1 and Rspo-2
✦ LIBER ✦
058 R-SPONDINS ARE NEW PLAYERS IN OSTEOARTHRITIS THAT REGULATE WNT SIGNALING IN OSTEOBLASTS
✍ Scribed by É. Abed; T. Chan; A. Delalandre; D. Lajeunesse
- Book ID
- 114351839
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 84 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1063-4584
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## Abstract The vertebrate hindbrain develops from a series of segments (rhombomeres) distributed along the anteroposterior axis. We are studying the roles of Wnt and Delta–Notch signaling in maintaining rhombomere boundaries as organizing centers in the zebrafish hindbrain. Several __wnt__ genes (