Quinolone antibiotics: Study of reactivi
โ
U.R. Kalkote; V.T. Sathe; R.K. Kharul; S.P. Chavan; T. Ravindranathan
๐
Article
๐
1996
๐
Elsevier Science
๐
French
โ 114 KB
The reaction of 7-ehloro-l-eyelopropyl-6-fluoro-4-oxo-l,2-dihydroquinoline-3earboxylie acid with piperazine in water was studied. The product eiprofloxacin was isolated and the impurity formed in the reaction was isolated and characterized as 1-cyelopropyl-7-chloro-6piperazinyl-4-oxo-l,2-dihydroquin