Quinolines and structurally related heterocycles as antimalarials
β Scribed by Kirandeep Kaur; Meenakshi Jain; Ravi P. Reddy; Rahul Jain
- Book ID
- 108116435
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 705 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0223-5234
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π SIMILAR VOLUMES
Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18-or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate
Despite emergence of resistance to CQ and other 4-aminoquinoline drugs in most of the endemic regions, research findings provide considerable support that there is still significant potential to discover new affordable, safe, and efficacious 4-aminoquinoline antimalarials. In present study, new side