Synthesis of 1,3-diamino-7,8,9,10-tetrah
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Joseph H. Chan; David P. Baccanari; Robert L. Tansik; Christine M. Boytos; Sharo
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Article
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1997
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Journal of Heterocyclic Chemistry
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English
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## Abstract A series of novel 1,3βdiaminoβ7,8,9,10βtetrahydropyrido[3,2β__f__]quinazolines were synthesized starting from 6βaminoβ5βcyanoquinoline (4). These compounds inhibited __Candida albicans__ dihydrofolate reductase with K~i~ values of β€0.60 a__M.__ One analogue exhibited moderate __in vivo_