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Quinazolines as inhibitors of dihydrofolate reductase. 1

✍ Scribed by Ashton, Wallace T.; Walker, F. C.; Hynes, John B.


Book ID
121500093
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
550 KB
Volume
16
Category
Article
ISSN
0022-2623

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Synthesis of 1,3-diamino-7,8,9,10-tetrah
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## Abstract A series of novel 1,3‐diamino‐7,8,9,10‐tetrahydropyrido[3,2‐__f__]quinazolines were synthesized starting from 6‐amino‐5‐cyanoquinoline (4). These compounds inhibited __Candida albicans__ dihydrofolate reductase with K~i~ values of ≀0.60 a__M.__ One analogue exhibited moderate __in vivo_