## Abstract CDK2 inhibitors containing the related bicyclic heterocycles pyrazolopyrimidines and imidazopyrazines were discovered through high‐throughput screening. Crystal structures of inhibitors with these bicyclic cores and two more related ones show that all but one have a common binding mode
Quantitative structure-activity relationships of cyclin-dependent kinase 1 inhibitors
✍ Scribed by A. V. Zakharov; A. A. Lagunin; D. A. Filimonov; V. V. Poroikov
- Book ID
- 111471982
- Publisher
- Pleiades Publishing
- Year
- 2007
- Tongue
- English
- Weight
- 182 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1990-7508
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Structure‐based quantitative structure‐activity relationship (QSAR) studies on a series of checkpoint kinase 1 (Chk1) inhibitors were performed to find the key structural features responsible for their inhibitory activity. Molecular docking was employed to explore the binding mode of al
## Abstract The cyclin‐dependent kinases or CDKs participate in the regulation of both the cell progression cycle and the RNA polymerase‐II transcription cycle. In several human tumours deregulation of CDK‐related mechanisms have been detected, e.g., overexpression of cyclins or deletion of genes e