Quantitative spectroscopic imaging with in situ measurements of tissue water T1, T2, and density

✍ Scribed by C. Gasparovic; H. Neeb; D.L. Feis; E. Damaraju; H. Chen; M.J. Doty; D.M. South; P.G. Mullins; H.J. Bockholt; N.J. Shah

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 284 KB
• Volume: 62
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.22060

✦ Synopsis

Abstract

The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy (^1^H‐MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel ^1^H‐MRS studies have often included measurements of water proton T~1~, T~2~, and density based on additional ^1^H‐MRS acquisitions (e.g., at multiple echo or repetition times), this approach is not practical for ^1^H‐MRS imaging (^1^H‐MRSI). In this report we demonstrate a method for using in situ measurements of water T~1~, T~2~, and density to calculate metabolite concentrations from ^1^H‐MRSI data. The relaxation and density data are coregistered with the ^1^H‐MRSI data and provide detailed information on the water signal appropriate to the individual subject and tissue region. We present data from both healthy subjects and a subject with brain lesions, underscoring the importance of water parameter measurements on a subject‐by‐subject and voxel‐by‐voxel basis. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.