Quantitative RNA slot-blot analysis of CCND1/cyclin D1 expression in suspected mantle cell lymphoma
โ Scribed by Mauvieux, L; Canioni, D; Hermine, O; Valensi, F; Radford-Weiss, I; Azagury, M; Magen, M; Flandrin, G; Brousse, N; Varet, B
- Book ID
- 110053716
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 175 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-6924
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The cyclin D1/CCND1 oncogene (PRAD1) is amplified in 15% of primary human breast cancers and overexpressed in 30-50% of breast cancers, suggesting that mechanisms in addition to DNA amplification may lead to deregulated expression of this gene in breast cancer. Cyclin D1 overexpression at a higher f
## Abstract In mantle cell lymphoma (MCL), minimal residual disease (MRD) is an indicator of the disease outcome. Quantitative methods used so far do not provide a suitable molecular marker in 30โ70% patients with MCL (depending on the technique used). We tested cyclin D1 as a marker for quantitati