Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and
β¦ LIBER β¦
High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
β Scribed by Islam, T C; Asplund, A C; Lindvall, J M; Nygren, L; Liden, J; Kimby, E; Christensson, B; Smith, C I E; Sander, B
- Book ID
- 110055588
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 284 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0887-6924
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Matrix metalloproteinase-1 (MMP-1) is one of only a few enzymes with the ability to degrade the stromal collagens (types I and III) at neutral pH, and high expression of MMP-1 has been associated with aggressive and invasive cancers. We recently reported a single nucleotide insertion/deletion polymo