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Quantitative MRI of spinal cord injury in a rat model

✍ Scribed by James C. Falconer; Ponnada A. Narayana; Meena B. Bhattacharjee; Shi-J. Liu

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
821 KB
Volume
32
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Sequential in vivo MRI studies of experimental spinal cord injuries (SCI) were performed using a three‐dimensional implementation of the FATE (Fast low‐Angle spin echo sequence with short TE) sequence. MRI‐observed pathology was quantified using a multispectral segmentation algorithm. Neurological analysis was performed on the same animals concurrently, in addition to end‐point histology, for comparison with quantitative MRI results. These studies suggest that it is possible to use MRI to detect the onset of secondary injury in the spinal cord. The data also indicate that early detection of MRI‐visible pathology may provide the necessary markers for predicting the long‐term level of neurologic deficit.

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