✦ LIBER ✦

MRI characterization of diffusion coefficients in a rat spinal cord injury model

✍ Scribed by John C. Ford; David B. Hackney; David C. Alsop; Hernan Jara; Peter M. Joseph; Christopher M. Hand; Perry Black

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 873 KB
Volume: 31
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910310504

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Apparent diffusion coefficients (ADC) were measured in a rat spinal cord weight‐drop injury model. After sacrifice, the spinal cords were fixed in situ and excised for MR imaging and ADC measurement. Diffusion is anisotropic in normal gray and white matter. There were significant decreases in ADCs measured along the longitudinal axis of the injured cord and increases in ADCs measured transverse to the cord. Injured segments demonstrated reductions in diffusion anisotropy in the white matter. Diffusion was completely isotropic at the epicenter of the weight‐drop injury. Significant decreases in longitudinal ADC and increases in transverse ADC were observed in portions of the cord which appeared normal on conventional spin‐echo and calculated T~2~ images. Thus ADC measurement may complement routine imaging for evaluation of spinal cord injury.

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