IGF-I, which is produced by intrauterine tissues including the placenta, has been implicated as a possible factor in intrauterine growth retardation (IUGR). We hypothesized that placental IGF-I production may be aberrant in pregnancies affected by IUGR. A placental perifusion system was utilized to
Quantitative microscopy in studies of intrauterine growth retardation
โ Scribed by Howard, C. Vyvyan
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 24 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0022-3417
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โฆ Synopsis
In the past, the detection of fetal damage has tended to be restricted to the naked eye identification of major malformations, with the period of organ maturation being relatively neglected. Increasingly, however, unbiased design-based stereology is being used in developmental toxicological studies. In the field of intrauterine growth retardation, such methods are capable of providing new insights into fetal vulnerability during critical periods in organogenesis, with consequences for both post-natal and adult disease. 1997
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In a pregnancy that was monitored due to increased risk for Down syndrome in the triple test, a normal karyotype was found in amniocentesis. Follow-up by serial ultrasound examinations revealed intrauterine growth retardation (IUGR) at 20 weeks of gestation. The parents decided to terminate the preg
Our recent findings that IGF-I inhibits placental thromboxane (TxB2) release (1, 2) and that prostanoid release from placentas or certain pregnancies complicated by intrauterine growth retardation (IUGR) is decreased [Sorem KA, Siler-Khodr TM, Placenta, 16:503-515, 1995] led us to investigate the ef
Prenatal history. Unenventful gestation of 36 weeks. Birth history. Born by cesarean section due to cephalopelvic disproportion. BW 2528 g ( < 3rd centile), BL 39.1 cm (< < 3rd centile), OFC within normal limits. Family history. Mother had a similar syndrome, born at term with a BW of 2272 g (< 3rd