✦ LIBER ✦

TRISOMY 2: CONFINED PLACENTAL MOSAICISM IN A FETUS WITH INTRAUTERINE GROWTH RETARDATION

✍ Scribed by ILANA ARIEL; ISRAELA LERER; SIMCHA YAGEL; RACHEL COHEN; ZIVA BEN-NERIAH; DVORAH ABELIOVICH

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 272 KB
Volume: 17
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199702)17:2<180::aid-pd31>3.0.co;2-#

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✦ Synopsis

In a pregnancy that was monitored due to increased risk for Down syndrome in the triple test, a normal karyotype was found in amniocentesis. Follow-up by serial ultrasound examinations revealed intrauterine growth retardation (IUGR) at 20 weeks of gestation. The parents decided to terminate the pregnancy and the karyotype of the placental fibroblasts was 47,XX,+2. Analysis of polymorphic markers of chromosome 2 demonstrated (a) that trisomy 2 was confined to the placenta (CPM), (b) that the trisomy 2 cell line was a result of a meiotic I error of paternal origin, and (c) that the fetal tissues with a normal karyotype were biparental disomy 2.

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