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Quantitative High-Performance Liquid Chromatography−Electrospray Ionization−Tandem Mass Spectrometry Analysis of the Adenine−Guanine Cross-Links of 1,2,3,4-Diepoxybutane in Tissues of Butadiene-Exposed B6C3F1 Mice

✍ Scribed by Goggin, Melissa; Anderson, Chris; Park, Soobong; Swenberg, James; Walker, Vernon; Tretyakova, Natalia

Book ID
126035728
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
540 KB
Volume
21
Category
Article
ISSN
0893-228X

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## Abstract Kahalalide F (KF) is a novel cyclic depsipeptide anticancer drug, which has shown anticancer activity both __in vitro__ and __in vivo__ especially against human prostate cancer cell lines. To characterize the pharmacokinetics of KF during a phase I clinical trial in patients with androg