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Quantitative High-Performance Liquid Chromatography−Electrospray Ionization Tandem Mass Spectrometry Analysis of Bis- N 7-Guanine DNA−DNA Cross-Links in White Blood Cells of Cancer Patients Receiving Cyclophosphamide Therapy

✍ Scribed by Malayappan, Bhaskar; Johnson, L’Aurelle; Nie, Bei; Panchal, Dolly; Matter, Brock; Jacobson, Pamala; Tretyakova, Natalia

Book ID: 125498659
Publisher: American Chemical Society
Year: 2010
Tongue: English
Weight: 524 KB
Volume: 82
Category: Article
ISSN: 0003-2700
DOI: 10.1021/ac902923s

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## Abstract High‐performance liquid chromatography (HPLC) was combined with electrospray ionization tandem mass spectrometry (ESI‐MS/MS) to develop a sensitive and selective method for the quantitative measurement of __N__^7^‐(2‐hydroxyethyl)guanine (__N__^7^‐HEG) adducts in DNA obtained from ethyl