Quantitative GLC determination of resorcinol monoacetate in dermatological products

✍ Scribed by Pramod P. Karkhanis; David O. Edlund; Jon R. Anfinsen

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 252 KB
• Volume: 62
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600620522

✦ Synopsis

nil because I is not as strong a base as I1 since only the latter contains a primary amino group. There was no interference from the antioxidant, sodium bisulfite (0.273, and the preservatives, methylparaben (0.02x) and propylparaben (0.OlX). The best pH range for the extraction of the phenylpropanolamine-dye complex with chloroform appears to be from 5.8 to 6.4 (Fig. ). A pH value of 6.4 was preferred for these studies due to low blank values. The effect of buffer concentration on the extraction of the complex appears to be negligible (Fig. ). To confirm this finding, three more amines (chlorpheniramine, ephedrine, and phenylephrine) were tested and the results were identical (Fig. ). Compound I can be easily assayed (Table ) using the Koshy-Mitchner method (2) with borate buffer without any interference from 11, the antioxidant, and the preservatives.