Quantitative genetic variation in carbonic anhydrase isozymes from tissues of the pig-tailed macaque,Macaca nemestrina

✍ Scribed by Verle E. Headings; Richard E. Tashian

• Publisher: Springer
• Year: 1971
• Tongue: English
• Weight: 768 KB
• Volume: 5
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485860

✦ Synopsis

Two isozymes of carbonic anhydrase (CA I and CA II) were quantified by a radioimmunoassay in 10 different tissues of the pig-tailed macaque. There were clearly differences in relative amounts of the two isozymes, indicating a differential regulation of these two different gene products. An inherited deficiency variant reduced red cell CA I and CA H 5000-fold and 2.7-fold, respectively. In nine other tissues, CA I was reduced from approximately twofold to l lO-fold, and CA H was essentially unchanged. The CA I in deficient red cells was immunochemically and electrophoretically identical to common eIectrophoretic variants of CA I in the pig-tailed macaque and was enzymatically active.