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Quantitative first-pass MRI measures increased myocardial perfusion after vasodilation in mice

✍ Scribed by Patrick Antkowiak; Christopher M Kramer; Craig H Meyer; Brent A French; Frederick H Epstein

Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 127 KB
Volume: 14
Category: Article
ISSN: 1097-6647
DOI: 10.1186/1532-429x-14-s1-p55

No coin nor oath required. For personal study only.

✦ Synopsis

We used first-pass contrast-enhanced MRI to quantatively measure the myocardial Ktrans, a parameter indicating myocardial perfusion and vascular permeability, in mice with or without vasodilation. We measured a significant increase in myocardial Ktrans with vasodilation. We believe this may be the first report showing that first-pass imaging can quantify increased myocardial perfusion in mice relative to baseline.

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