Quantitative myocardial perfusion analysis with a dual-bolus contrast-enhanced first-pass MRI technique in humans

✍ Scribed by Li-Yueh Hsu; Kenneth L. Rhoads; Jessica E. Holly; Peter Kellman; Anthony H. Aletras; Andrew E. Arai

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 633 KB
• Volume: 23
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.20502

✦ Synopsis

Abstract

Purpose

To compare fully quantitative and semiquantitative analysis of rest and stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) using a dual‐bolus first‐pass perfusion MRI method in humans.

Materials and Methods

Rest and dipyridamole stress perfusion imaging was performed on 10 healthy humans by administering gadolinium contrast using a dual‐bolus protocol. Ventricular and myocardial time‐signal intensity curves were generated from a series of T1‐weighted images and adjusted for surface‐coil intensity variations. Corrected signal intensity curves were then fitted using fully quantitative model constrained deconvolution (MCD) to quantify MBF (mL/min/g) and MPR. The results were compared with semiquantitative contrast enhancement ratio (CER) and upslope index (SLP) measurements.

Results

MBF (mL/min/g) estimated with MCD averaged 1.02 ± 0.22 at rest and 3.39 ± 0.59 for stress with no overlap in measures. MPR was 3.43 ± 0.71, 1.91 ± 0.65, and 1.16 ± 0.19 using MCD, SLP, and CER. Both semiquantitative parameters (SLP and CER) significantly underestimated MPR (P < 0.001) and failed to completely discriminate rest and stress perfusion.

Conclusion

Rest and stress MBF (mL/min/g) and MPR estimated by dual‐bolus perfusion MRI fit within published ranges. Semiquantitative methods (SLP and CER) significantly underestimated MPR. J. Magn. Reson. Imaging 2006. Published by Wiley‐Liss, Inc.