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Quantitative ex vivo and in vitro receptor autoradiography using 11C-labeled ligands and an imaging plate: a study with a dopamine D2-like receptor ligand [11C]nemonapride

✍ Scribed by Kiichi Ishiwata; Nobuo Ogi; Akira Tanaka; Michio Senda

Book ID: 117688362
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 377 KB
Volume: 26
Category: Article
ISSN: 0969-8051
DOI: 10.1016/s0969-8051(98)00115-2

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## Abstract Iodobenzamide (IMB) labeled with either [^11^C] or [^125^I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D~2~ dopamine receptors. Mouse biodistribution studies with both [^11^C]IMB and [^125^I]IMB showed a similar brain