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Quantitative estimation of the density ratios of cholinesterase isoenzyme bands in human amniotic fluid in the prenatal diagnosis of malformed fetus

✍ Scribed by Yong-mu, Huangfu ;Pu-qing, Jiang ;Ping, Li ;Chun-ben, Wang ;Shan-shu, He


Book ID
112927510
Publisher
Springer-Verlag
Year
1988
Tongue
English
Weight
705 KB
Volume
8
Category
Article
ISSN
0257-716X

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Amniotic fluid cholinesterase of valproa
✍ Mohamed M. A. Elmazar; Richard Vogel; Horst Spielmann πŸ“‚ Article πŸ“… 1988 πŸ› Springer-Verlag 🌐 English βš– 321 KB

After a single administration of the antiepileptic drug valproic acid (VPA; i.p.:600 mg/kg) on day 8 of gestation in the mouse embryotoxicity and amniotic fluid (AF) cholinesterase (ChE) were evaluated on day 16 of gestation. VPA treatment induced an increase in embryolethality, neural tube defects