Quantitative and qualitative assay of amniotic-fluid acetylcholinesterase in the prenatal diagnosis of neural tube defects
✍ Scribed by Theda Voigtländer; Waltraud Friedl; Marion Cremer; W. Schmidt; Traute M. Schroeder
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 702 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0340-6717
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📜 SIMILAR VOLUMES
After a single administration of the antiepileptic drug valproic acid (VPA; i.p.:600 mg/kg) on day 8 of gestation in the mouse embryotoxicity and amniotic fluid (AF) cholinesterase (ChE) were evaluated on day 16 of gestation. VPA treatment induced an increase in embryolethality, neural tube defects
## Cytologic evaluation of second trimester amniotic fluid (AF) is a rapid, inexpensive adjunct to prenatal diagnosis of open neural tube defects (ONTDs). Our goal was to determine whether the neural-appearing cells and/or large foamy macrophages in the AF of anencephalics are indeed of neural and