Quantitative and qualitative changes in RNA metabolism in rats fed N-2-acetylaminofluorene
✍ Scribed by Garth E. Austin; Geoffrey H. Moyer
- Book ID
- 113147151
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 802 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0014-4800
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## Abstract The effects of feeding a choline‐devoid (CD) or a choline‐supplemented (CS) diet on the induction of liver tumors in rats by 2‐acetylaminofluorene (AAF) were investigated. Male Sprague‐Dawley rats were fed either a CD or a CS diet containing 0.0075% AAF. Three to eight animals were kill
## Abstract In this study, the mutation frequencies of the p53 gene in rat hepatocellular carcinomas (HCCs) induced by __N__‐nitroso‐2‐acetylaminofluorene (NO‐AAF) and 2‐acetylaminofluorene (AAF) were 19.23% (20 of 104) and 31.1% (33 of 106), respectively. Four noteworthy features of the mutation s