Quantitative analysis of intestinal ulceration induced by indomethacin, in rats
✍ Scribed by E. Ezer
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1987
- Tongue
- English
- Weight
- 216 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1420-908X
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📜 SIMILAR VOLUMES
## Abstract Gastric mucosal ulceration was produced in rats following intraperitoneal injection of indomethacin (40 mg/kg). The incidence of ulcerations was progressively reduced as the bile flow was diverted progressively distal to the ampulla of Vater. It is suggested that bile reflux into the st
Encapsulation of indomethacin into egg phosphatidylcholine (EPC) monophasic vesicles (MPV) or into stable plurilamellar vesicles (SPLV) before oral administration to rats substantially reduced or eliminated the gastric and intestinal ulceration normally associated with ingestion of this drug. Ulcers