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Quantitation of precipitating antibodies to certain soluble nuclear antigens in sle

✍ Scribed by Peter J. Maddison; Morris Reichlin

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
538 KB
Volume
20
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

Electrophoresis in polyacrylamide gels in the presence of sodium dodecyl sulfate was used to separate and quantitate the components of a washed immune precipitate. Serum was from patients with systemic lupus erythematosus known to have antibodies to soluble nuclear ribonucleoprotein (RNP) or to a soluble nuclear non‐nucleic acid protein (Sm). Amounts of antibody that was predominantly IgG ranged from 0.2 to 8 mg/ml of patients' serum, and in some cases accounted for over 20% of the total serum IgG. Results demonstrate that some patients respond to the disease by producing large amounts of a specific antibody, and that these antibodies can contribute significantly to hypergammaglobulinemia.

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