The Precipitating Antibody to an Acidic Nuclear Protein Antigen, the Jo-1, in Connective Tissue Diseases

✍ Scribed by Shunji Yoshida; Masashi Akizuki; Tsuneyo Mimori; Hajime Yamagat; Shinichi Inada; Mitsuo Homma

• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 752 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260505

✦ Synopsis

The clinical significance of antibodies to the Jo-1 antigen in connective tissue diseases was studied. Clinical diagnoses of 11 patients who had anti-Jo-1 antibody were: polymyositis 8, dermatomyositis 1, and overlap syndrome 2 (polymyositis--systemic lupus erythematosus 1, polymyositis--scleroderma 1). All the patients who had anti-Jo-1 antibody showed interstitial pulmonary fibrosis, and in 2 patients anti-Jo-1 antibodies were detected before the appearance of lung disease.