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Quantitation of lidocaine and its deethylated metabolites in plasma and urine by gas chromatography-mass fragmentography

โœ Scribed by Charles E. Hignite; Christian Tschanz; Janice Steiner; David H. Huffman; Daniel L. Azarnoff

Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
512 KB
Volume
161
Category
Article
ISSN
1873-3778

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โœฆ Synopsis

A sensitive, precise and accurate method for simultaneous quantitation of lidocaine and its deethylated metabolites by gas chromatography-mass fragmentography has been developed. Propyl derivatives of the deethylated metabolites are formed directly in either plasma or urine by treatment with propionaldehyde and sodium cyanoborohydride.

The propyl derivatives and unchanged lidocaine are extracted, separated by gas chromato,wphy and quantitated by mass framentography using mepivacaine as the internal standard. Quantitation of these compounds to levels as low as 50 ng/ml body fluid has been achieved with coefficients of variation less than 10%.

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