Quantitation of iprindole in plasma by GLC

✍ Scribed by G. Caillé; C. De Montigny; J-G. Besner

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 329 KB
• Volume: 3
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510030103

✦ Synopsis

Abstract

A specific, sensitive, rapid, and reproducible method for iprindole in human plasma was developed using gas chromatography with trimipramine as internal standard. The sensitivity of the method is of S ng ml^−1^ and a linearity was obtained for concentrations ranging from 12.5ngml^−1^ to 100ngml^−1^ with a regression coefficient of 0.9872. The plasma levels of iprindole were determined in five healthy volunteers following the administration of a single oral dose of 60 mg and in four patients admitted for endogenous depression after a 3‐week administration of 90mgd^−1^. Following a single oral dose to healthy volunteers, the maximum concentrations occurred between 2 and 4h after administration of the drug and the mean half‐life value was 52.5 h. In patients the steady‐state concentrations of iprindole ranged between 18 and 77ngml^−1^.