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Quantitation of heteroplasmy of mitochondrial trnaLeu(UUR) gene using PCR-SSCP

โœ Scribed by Dr. Yoshinori Tanno; Dr. Makoto Yoneda; Dr. Keiko Tanaka; Dr. Hajime Tanaka; Dr. Motoyoshi Yamazaki; Dr. Masatoyo Nishiawa; Dr. Koichi Wakabayashi; Dr. Eisaku Ohama; Dr. Shoji Tsuji


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
854 KB
Volume
18
Category
Article
ISSN
0148-639X

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To investigate the prevalence and clinical characteristics of diabetes mellitus caused by mitochondrial gene mutations in the tRNA Leu(UUR) region, a known 'hot spot' for pathogenic mutations, we screened 440 diabetic patients with diabetic mothers for 11 mitochondrial gene mutations reported in mit