ESTIMATING THE PROPORTION OF TREATMENT E
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D. Y. LIN; T. R. FLEMING; V. DE GRUTTOLA
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Article
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1997
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John Wiley and Sons
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English
β 362 KB
In this paper, we measure the extent to which a biological marker is a surrogate endpoint for a clinical event by the proportional reduction in the regression coefficient for the treatment indicator due to the inclusion of the marker in the Cox regression model. We estimate this proportion by applyi