𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An Evaluation of a Measure of the Proportion of the Treatment Effect Explained by a Surrogate Marker

✍ Scribed by Paul W Bycott; Jeremy M.G Taylor

Book ID
114187524
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
176 KB
Volume
19
Category
Article
ISSN
0197-2456

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

ESTIMATING THE PROPORTION OF TREATMENT E
ESTIMATING THE PROPORTION OF TREATMENT EFFECT EXPLAINED BY A SURROGATE MARKER
✍ D. Y. LIN; T. R. FLEMING; V. DE GRUTTOLA πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 362 KB

In this paper, we measure the extent to which a biological marker is a surrogate endpoint for a clinical event by the proportional reduction in the regression coefficient for the treatment indicator due to the inclusion of the marker in the Cox regression model. We estimate this proportion by applyi

Estimating the proportion of treatment e
Estimating the proportion of treatment effect explained by a surrogate marker by D. Y. Lin, T. R. Fleming and V. De Gruttola, Statistics in Medicine, 16, 1515–1527 (1997)
✍ Philippe Flandre; Yacine Saidi πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 56 KB

Lin, Fleming and DeGruttola (LFD) address the important problem of estimating the proportion of treatment effect (PTE) explained by a surrogate marker. Problems of interpretation of the measure as well as the theoretical basis of its formulation are well explained. This measure has been introduced t