## Abstract On examination of cDNA of the p53 gene in 65 murine tumors of the skin and bone produced by repeated exposure to a suprathreshold dose of 1β8 Gy of ^90^Srβ^90^Y Ξ²βradiation per exposure, we found 20 cases of mutation: 11 minute deletions (loss of 1β24bp), including two cases possibly du
β¦ LIBER β¦
Quantifying levels of p53 mutation in mouse skin tumors
β Scribed by Tracie L. Verkler; Letha H. Couch; Paul C. Howard; Barbara L. Parsons
- Book ID
- 102191970
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 242 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.20108
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Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana