## Abstract Sunlight and ultravioletβinduced mutation of the __p53__ gene is a frequent, possibly obligate step in skin cancer development, making quantitative measurement of __p53__ mutation an ideal biomarker for sunlightβinduced skin carcinogenesis. To understand how the appearance of __p53__ mu
p53 Mutations in Hairless SKH-hr1 Mouse Skin Tumors Induced by a Solar Simulator
β Scribed by Honnavara N. Ananthaswamy; Anny Fourtanier; Randall L. Evans; Sylvie Tison; Chantal Medaisko; Stephen E. Ullrich; Margaret L. Kripke
- Book ID
- 111412431
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 650 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0031-8655
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We investigated skin lesions induced in hairless SKH:HR1 mice by chronic exposure to a solar ultraviolet light (UV) simulator for alterations of the p53 gene in conserved domains. Mutations of exons 5-8 of the p53 gene in skin lesions were screened in 31 benign skin lesions (hyperplasias), 25 precan
## Abstract The __p53__ codon 270 CGT to TGT mutation was investigated as a biomarker of sunlightβinduced mutagenesis and carcinogenesis. The relationship between tumor development and abundance of this hotspot mutation was analyzed in mouse skin tumors induced by chronic exposure to simulated sola
## Abstract Combined subcarcinogenic doses of benzo[__a__]pyrene (BaP) and UVA induced Hβ__ras,__ but not __p53,__ gene mutations 8 weeks before tumor emergence in SKHβ1 mice. Neither UVA (40 kJ/m^2^) nor BaP (8 nmol) induced any tumors after mice were topically treated 3 times/week for 25 weeks. H