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p53 Gene Mutations in SKH-1 Mouse Tumors Differentially Induced by UVB and Combined Subcarcinogenic Benzo[a]pyrene and UVA

✍ Scribed by Yongyin Wang; Xueyan Zhou; Elhav Weinstein; Billie Maryles; Yanzhen Zhang; Julian Moore; Dayuan Gao; David P. Atencio; Barry S. Rosenstein; Mark Lebwohl; Hong-Duo Chen; Ting Xiao; Huachen Wei

Book ID: 111413173
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 164 KB
Volume: 84
Category: Article
ISSN: 0031-8655
DOI: 10.1111/j.1751-1097.2007.00282.x

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## Abstract Combined subcarcinogenic doses of benzo[__a__]pyrene (BaP) and UVA induced H‐__ras,__ but not __p53,__ gene mutations 8 weeks before tumor emergence in SKH‐1 mice. Neither UVA (40 kJ/m^2^) nor BaP (8 nmol) induced any tumors after mice were topically treated 3 times/week for 25 weeks. H