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Quantification of expression of netrins, slits and their receptors in human prostate tumors

✍ Scribed by Alain Latil; Laurent Chêne; Béatrix Cochant-Priollet; Philippe Mangin; Georges Fournier; Philippe Berthon; Olivier Cussenot

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
609 KB
Volume
103
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Recently, DCC (Deleted in Colorectal Cancer) protein has been forwarded as a receptor for netrin. The Netrin/DCC complex is critical for axon guidance and cell migration. In the developing nervous system, netrin protein secreted by midline cells attracts commissural axons by activating the DCC receptor on growth cones. This attraction can be switched to repulsion or silenced completely, depending on the DCC binding partner. The potential suppressor function of DCC in prostate tumorigenesis, through a still unknown mechanism, prompted us to quantify the expression of several genes involved in this axon guidance pathway. The relative expression levels of DCC, NEO1, NTN1, NTN2L, NTN4, UNC5C, Slit1, Slit2, Slit3, Robo1 and Robo2 were simultaneous quantified in 48 tumors and 7 normal prostate tissues by using real‐time quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR). A reduction in DCC, NEO1, NTN1 and NTN4 expression was observed in prostate tumors, while many of the same prostate tumors over‐expressed either Slit genes or their receptors, Robo. © 2002 Wiley‐Liss, Inc.

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