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Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized 3He magnetic resonance imaging

✍ Scribed by Tina A. Lewis; Yang-Sheng Tzeng; Erin L. McKinstry; Angela C. Tooker; Kwansoo Hong; Yanping Sun; Joey Mansour; Zachary Handler; Mitchell S. Albert

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
295 KB
Volume
53
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

As another step toward extracting quantitative information from hyperpolarized ^3^He MRI, airway diameters in humans were measured from projection images and multislice images of the lungs. Values obtained were in good agreement with the Weibel lung morphometry model. The measurement of airway caliber can now be achieved without the use of ionizing radiation. Furthermore, it was demonstrated that 3D airway tree renderings could be constructed from the multislice data. Both the measurement of airway diameters and the rendering of 3D airway information hold promise for the clinical assessment of bronchoconstrictive diseases such as asthma and the associated evaluation of treatment effectiveness. Work is being done to address the uncertainties of the manually intensive methods we have developed. Magn Reson Med 53:474–478, 2005. © 2005 Wiley‐Liss, Inc.

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