Comparison of airway diameter measurements from an anthropomorphic airway tree phantom using hyperpolarized 3He MRI and high-resolution computed tomography
✍ Scribed by Yang-Sheng Tzeng; Eric Hoffman; Janice Cook-Granroth; Rie Maurer; Niral Shah; Joey Mansour; Juerg Tschirren; Mitchell Albert
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 283 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
An anthropomorphic airway tree phantom was imaged with both hyperpolarized (HP) ^3^He MRI using a dynamic projection scan and computed tomography (CT). Airway diameter measurements from the HP ^3^He MR images obtained using a newly developed model‐based algorithm were compared against their corresponding CT values quantified with a well‐established method. Of the 45 airway segments that could be evaluated with CT, only 14 airway segments (31%) could be evaluated using HP ^3^He MRI. No airway segments smaller than ∼4 mm in diameter and distal to the fourth generation were adequate for analysis in MRI. For the 14 airway segments measured, only two airway segments yielded a non‐equivalent comparison between the two imaging modalities, while eight more had inconclusive comparison results, leaving only four airway segments (29%) that satisfied the designed equivalence criteria. Some of the potential problems in airway diameter quantification described in the formulation of the model‐based algorithm were observed in this study. These results suggest that dynamic projection HP ^3^He MRI may have limited utility for measuring airway segment diameters, particularly those of the central airways. Magn Reson Med 58:636–642, 2007. © 2007 Wiley‐Liss, Inc.