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Quantification and stability of Salbutamol in human urine

✍ Scribed by Guro Forsdahl; Günter Gmeiner

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
171 KB
Volume
27
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

A sensitive method for the quantification of free salbutamol in human urine is described. Sample clean up is performed using SPE on a mixed phase extraction column. Derivatisation is performed with N‐methyl‐N‐trimethylsilyltrifluoroacetamide (MSTFA) and the extract is analysed by GC‐MS. The method was found to be suitable for use in the doping field, where a cut‐off limit of 1 μg salbutamol/mL urine is set by the International Olympic Committee (IOC) and approved by the World Anti‐Doping Agency (WADA). Above that value a doping violation occurs. In addition, the stability of salbutamol in human urine has been evaluated.

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