Metabolites of naloxone in human urine

✍ Scribed by S. H. Weinstein; M. Pfeffer; J. M. Schor; L. Indindoli; M. Mintz

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 249 KB
• Volume: 60
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600601030

✦ Synopsis

ical technique employed for dissolution studies, one must verify that the excipients present in the formulations indeed do not interfere with the titration assay. The titration method cannot be employed in studying dissolution of capsule formulations, since the acidic nature of gelatin capsules causes overlap with the titration assay of the drug. In the automated spectrophotometric method, the dissolution fluid has to be filtered and then externally circulated through a photometric cell. Therefore, clogging of the filter screen and the lag time involved between the actual dissolution of the drug and its spectrophotometric measurement are the obvious problems encountered with this method. In the titration technique, however, these problems are nonexistent because the dissolution fluid does not have to be filtered or externally circulated.

(4) A.