We assessed the naturally occurring T-cell immune response in primary renal cell carcinoma (RCC) tumors from 12 unselected patients. A predominance of CD3 1 T-cell receptor (TCR)a/b 1 T cells was observed in tumor-infiltrating lymphocytes (TILs), in contrast with peripheral blood lymphopenia found i
β¦ LIBER β¦
QUANTIFICATION AND IN SITU LOCALIZATION OF MCP-1 mRNA AND ITS RELATION TO THE IMMUNE RESPONSE OF RENAL CELL CARCINOMA
β Scribed by B. Hemmerlein; U. Johanns; A. Kugler; M. Reffelmann; H.-J. Radzun
- Book ID
- 115596633
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 799 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1043-4666
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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio