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Quality by design: understanding the formulation variables and optimization of metformin hydrochloride 750

✍ Scribed by Young-Lae Lee, Min-Soo Kim, Myung-Yong Park, Kun Han

Book ID
118305007
Publisher
Springer Netherlands
Year
2012
Tongue
English
Weight
387 KB
Volume
42
Category
Article
ISSN
2093-5552

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The objective of this study was to examine the effects of testing parameters and formulation variables on the segregation tendency of pharmaceutical powders measured by the ASTM D 6940-04 segregation tester using design of experiments (DOE) approaches. The test blends consisted of 4% aspirin (ASP) a