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Pyruvate kinase deficiency: providing protection from Plasmodium parasitism

โœ Scribed by BA Coburn


Book ID
110725699
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
890 KB
Volume
65
Category
Article
ISSN
0009-9163

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โœ Charles A. Koller; Eugene P. Orringer; John C. Parker ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 417 KB

## Abstract Pyruvate kinase deficient red blood cells have an abnormal tendency to lose ATP when exposed to low pO~2~ or cyanide, whereas normal red cells do not. Once energy is depleted, all red cells take up calcium and subsequently lose intracellular potassium and water. It has been shown previo